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Year : 2012  |  Volume : 1  |  Issue : 1  |  Page : 41-48

Electroreduction of tacrolimus as immunosuppressant agent at hanging mercury drop electrode: Application to determination in pharmaceutical formulation

1 Medical Biology Research Center, Kermanshah University of Medical Science; School of Pharmacy, Kermanshah University of Medical Science, Kermanshah, Iran
2 Department of Chemistry, Faculty of Science, Razi University, Kermanshah, Iran
3 School of Pharmacy, Kermanshah University of Medical Science, Kermanshah, Iran

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The adsorptive behavior of the immunosuppressive agent tacrolimus was studied by cyclic and differential-pulse voltammetry on a hanging mercury drop electrode (HMDE). The drug was accumulated at HMDE and two well-defined peak currents were obtained at -1353 and -1417 mV vs. SCE (saturated KCl) in borate buffer (pH 10.0) + 0.1 KCl solution. A voltammetric procedure was developed for the determination of tacrolimus using differential-pulse adsorptive stripping voltammetry (DPAdSV). The optimum working conditions for determination of the drug were established. The analysis of tacrolimus in pharmaceutical dosage forms was carried out satisfactorily.

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