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RESEARCH ARTICLE
Year : 2012  |  Volume : 1  |  Issue : 1  |  Page : 60-66

Synthesis and characterization of hydrazide-hydrazone derivatives of 3-pyridine carboxylic acid as antimycobacterial tuberculosis agents


1 Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, and Pharmaceutical Sciences Research Network, Ministry of Health, Treatment and Medical Education, Tehran, Iran
2 Depatrment of Biology and Microbiology, Faculty of Medicine, Islamic Azad University, Parand Branch; Masoud Laboratory, Department of Mycobacteriology, Tehran, Iran

Correspondence Address:
Hadi Adibi
Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran and Pharmaceutical Sciences Research Network, Ministry of Health, Treatment and Medical Education, Tehran
Iran
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Source of Support: None, Conflict of Interest: None


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In this study synthesis of nicotinoyl hydrazone derivatives is investigated by introducing the nicotinicacidhydrazidepharmacophore into several molecules and screening for antimycobacterial activity. Benzaldehyde derivatives react with nicotinicacidhydrazideto form nicotinoylhydrazones. The synthesized compounds were screened against M. tuberculosis H37Rv, clinical isolates of M. tuberculosis and MDR clinical isolates of M. tuberculosisusing the proportion test. The minimum inhibitory concentration (MIC) of N'-(4-methylphenyl) nicotinicacidhydrazone and N'-(4-(N,N-dimethyl)phenyl)nicotinicacidhydrazone exhibited activity between 40 and 200μg/mL and could be a good start point to find new lead compounds against M. tuberculosis.


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