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Year : 2013  |  Volume : 2  |  Issue : 2  |  Page : 103-110

Dispersive liquid-liquid micro-extraction as a sample preparation method for clonazepam analysis in water samples and pharmaceutical preparations

Department of Chemistry, Razi University, Kermanshah, Iran

Correspondence Address:
Fahimeh Jalali
Department of Chemistry, Razi University, Kermanshah
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Source of Support: None, Conflict of Interest: None

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Dispersive liquid–liquid micro–extraction (DLLME) technique was successfully used as a sample preparation method for the determination of clonazepam in pharmaceutical preparations and water samples. In this method, a suitable mixture of methanol (disperser solvent) and chloroform (extraction solvent) was injected rapidly into a conical test tube that contained an aqueous solution of clonazepam. After centrifuging, phase separation was performed by sedimenting the fine droplets of the micro–extraction solvent on the bottom of a test tube (about 100 μL) and then the absorbance of the enriched extracted phase was determined at the absorption wavelength of clonazepam (307 nm). Some important parameters such as, the type and volume of extraction and dispersive solvents as well as the extraction time were investigated and optimized. Under the optimum conditions, the calibration graph was linear over the range of 0.95 to 18.94 μg/mL of clonazepam with a limit of detection of 0.06 μg/ml.

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