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Year : 2015  |  Volume : 4  |  Issue : 1  |  Page : 24-29

Effect of Tribulus Terrestris aqueous extract on survival and growth of human peripheral blood mononuclear cells (Hpbmc) and several cancerous cell lines

1 Department of immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Correspondence Address:
Ali Mostafaie
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah
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Source of Support: None, Conflict of Interest: None

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Tribulus terrestris (TT) is a member of the Zygophyllaceae family. Traditional Chinese medicine recommends the use of TT for treatment of a variety of diseases. In the present study we further investigated antiproliferative and cytotoxic effects of TT extract on normal and several malignant cell lines. For this purpose, TT was collected and after authentication, aqueous extract was prepared. Cytotoxic activity of TT extract at different doses (5-640μg/ml) was determined by LDH assay. Proliferative activity of TT extract was determined by trypan blue staining and cell counting methods. The results showed that IC50 of the extract for cancer cell line is 320 μg/ml and it is higher for hPBMC. On the other hand, we observed proliferative effect of TT extract on hPBMC but not on malignant cell lines.

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