• Users Online: 240
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
RESEARCH ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 3  |  Page : 357-367

The anti-atherosclerotic effect of Prosopis Farcta is associated with the inhibition of VCAM-1 and ICAM-1


1 Medical Biology Research Center; School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Students research committee, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
5 School of Pharmacy; Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran

Correspondence Address:
Mohammad Hosein Farzaei
School of Pharmacy; Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

This study evaluated the anti-atherosclerosis effect of aqueous extract and polysaccharide-enriched fraction of Prosopis farcta on adhesion and inflammatory cascades in vascular endothelial cells and related molecular mechanisms. Cellular toxicities of LPS, plant extract and polysaccharide-enriched fraction were analyzed in vitro using the MTT method. The ROS accumulation, mRNA expression of ICAM1 and VCAM1, and COX activity were measured in HUVEC cells. These results revealed a new underlying mechanism for anti-atherosclerosis effect of P. farcta and polysaccharide-enriched fraction by attenuating inflammatory cascade mediated by COX expression, modulating expression of cell- adhesion molecules including VCAM-1 and ICAM-1, and diminishing oxidative stress agents.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed949    
    Printed69    
    Emailed0    
    PDF Downloaded174    
    Comments [Add]    

Recommend this journal