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The anti-atherosclerotic effect of Prosopis Farcta is associated with the inhibition of VCAM-1 and ICAM-1
Gholamreza Bahrami1, Leila Hosseinzadeh2, Zahra Azadi3, Bahareh Mohammadi4, Zahra Mahdiyan3, Marziyeh Hajialyani2, Mohammad Hosein Farzaei5
1 Medical Biology Research Center; School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Students research committee, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
5 School of Pharmacy; Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
Correspondence Address:
Mohammad Hosein Farzaei
School of Pharmacy; Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
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This study evaluated the anti-atherosclerosis effect of aqueous extract and polysaccharide-enriched fraction of Prosopis farcta on adhesion and inflammatory cascades in vascular endothelial cells and related molecular mechanisms. Cellular toxicities of LPS, plant extract and polysaccharide-enriched fraction were analyzed in vitro using the MTT method. The ROS accumulation, mRNA expression of ICAM1 and VCAM1, and COX activity were measured in HUVEC cells. These results revealed a new underlying mechanism for anti-atherosclerosis effect of P. farcta and polysaccharide-enriched fraction by attenuating inflammatory cascade mediated by COX expression, modulating expression of cell- adhesion molecules including VCAM-1 and ICAM-1, and diminishing oxidative stress agents.
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