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Year : 2021  |  Volume : 10  |  Issue : 1  |  Page : 71-76

The wound healing effect of allogeneic freeze-dried platelet-rich plasma in a full-thickness wound animal model

1 Faculty of Medicine, Airlangga University - General Hospital of Dr. Soetomo, Surabaya, Indonesia
2 Department of Veterinary Clinic, Faculty of Veterinary Medicine, Airlangga University, Surabaya, Indonesia
3 Study Program of Pharmacy, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia

Correspondence Address:
Oki N Putra
M.Clin.Pharm, Study Program of Pharmacy, Faculty of Medicine, Hang Tuah University, Surabaya.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jrptps.JRPTPS_77_19

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Background: Epithelialization is an indicator of wound healing. Platelet-rich plasma (PRP) may accelerate the epithelialization of the wound due to high amount of growth factors. Generally, allogeneic PRP provides a smaller immunological effect than autologous PRP. By a freeze-drying method, it is assumed that allogeneic PRP has lower allergenic activity. Aims and Objectives: The aim of this study was to investigate the effect of allogeneic freeze-dried PRP on wound healing of a full-thickness wound in New Zealand rabbits. About 2 × 2 cm2 full-thickness wounds were created on rabbits using a template on both sides of the dorsum and divided into treatment group and control group. The treatment group was treated with allogeneic freeze-dried PRP and the control group was treated with moist dressing. Acceleration of wound healing was shown by the epithelialization and measured on day 7 using digital Visitrak. Nine New Zealand rabbits were used in this study. Results: In the treatment group, the epithelialization was significantly higher 3.00 ± 0.96 cm2 than the control group 1.35 ± 0.85 cm2 (P < 0.000) by independent t test. Another finding of our study was the allergic reaction was not observed after the administration of allogeneic freeze-dried PRP in rabbits. Conclusion: Our results indicate that allogeneic freeze-dried PRP accelerates epithelialization compared to the control group and does not cause an allergic reaction in full-thickness wounds in rabbits. The effect of allogeneic PRP, prepared with a freeze-drying method, on the process of wound healing is reported for the first time in this article.

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