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Year : 2021  |  Volume : 10  |  Issue : 2  |  Page : 198-208

Solid SMEDDS: An approach for dissolution rate enhancement using telmisartan as model drug

1 Department of Pharmaceutics, MGV’S Pharmacy College, Nashik, Maharashtra, India
2 Department of Pharmaceutics, Sandip Institute of Pharmaceutical Sciences, Nashik, Maharashtra, India
3 Department of Pharmaceutics, Divine College of Pharmacy, Nashik, Maharashtra, India
4 Department of Pharmaceutics, MVP’s College of Pharmacy, Nashik, Maharashtra, India

Correspondence Address:
Dr. Ashish Y Pawar
Department of Pharmaceutics, MGV’S Pharmacy College, Panchavati, Nashik, Maharashtra 422 003.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jrptps.JRPTPS_6_20

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Bioavailability improvement of poorly water-soluble drugs is a challenging task for many of the drug candidates. In recent years, an area that is ahead in popularity for different formulation expertise is the use of lipid-based careers to formulate self-emulsifying drug delivery systems (SEDDS) for enhancing the oral bioavailability of lipophilic drugs. The self-microemulsifying drug delivery systems (SMEDDS) are thermodynamically stable and isotropic solutions containing an oil, surfactant, co-surfactant (CoS; or solubilizer), and mixtures of drug which forms oil-in-water microemulsions when incorporated in water and stirred. Different techniques are available to convert liquid–self-microemulsifying drug delivery systems (L-SMEDDS) to solid among which an adsorption technique is economical and very simple. The solid–self-microemulsifying drug delivery systems (S-SMEDDS) of telmisartan (TEL) was developed in the present study which is a poorly water-soluble drug. Different formulations of L-SMEDDS were developed using Capmul PG 8 as oil, Cremophor RH 40 as a surfactant, and Transcutol P as a CoS and were later transformed to S-SMEDDS. The formulations were assessed for dilution study by visual observation, differential scanning calorimetry, analysis of solid S-SMEDDS morphologically, in vitro dissolution test, zeta potential measurement, etc. Significantly higher drug release was observed from S-SMEDDS as compared to plain TEL. Hence, it can be concluded that the adsorption technique is a promising approach for the formulation of S-SMEDDS with improved dissolution rate and concomitantly bioavailability.

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