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Year : 2021  |  Volume : 10  |  Issue : 2  |  Page : 247-255

Antidiabetic potential yacon (Smallanthus sonchifolius (Poepp.) H. Rob.) leaf extract via antioxidant activities, inhibition of α-glucosidase, α-amylase, G-6-Pase by in vitro assay

1 Faculty of Medicine, Maranatha Christian University, Jl. Prof. drg. Surya Sumantri no. 65 Bandung 40164, West Java, Indonesia
2 Aretha Medika Utama, Biomolecular and Biomedical Research Center, Jl. Babakan Jeruk 2 no.9 Bandung 40163, West Java, Indonesia
3 Faculty of Medicine, Universitas Prima Indonesia, Jl. Belanga No. 1 Simp. Ayahanda, Medan 20118, North Sumatera, Indonesia
4 Faculty of Technobiology, Universitas Katolik Indonesia Atmajaya, Jl. Cisauk, BSD, Tangerang Selatan 15345, Banten, Indonesia

Correspondence Address:
Dr. Wahyu Widowati
Faculty of Medicine, Maranatha Christian University, Jl. Prof. drg., Surya Sumantri no. 65 Bandung 40164, West Java.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jrptps.JRPTPS_3_21

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Background: Diabetes is a chronic disease characterized by glucose levels and results in impaired insulin secretion. This disorder has triggered oxidative stress and excess free radicals condition. Smallanthus sonchifolius is a traditional medicine that acts as a diabetic therapy. This research aims to bring out the antidiabetic and antioxidant potential of S. sonchifolius extract (SSE). Materials and Methods: This study was conducted to measure the qualitative phytochemical identification, antioxidant and anti-diabetic activity of SSE. The antioxidant assay was carried out using 2,2-diphenyl-1-picrylhydrazine (DPPH)-scavenging activity, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS)-scavenging and hydrogen peroxide (H2O2)-reducing activity assays, ferric reducing antioxidant power (FRAP) potency, while anti-diabetic activity of SSE assay was carried out using inhibitory of α-amylase, α-glucosidase, and Glucose-6-Phosphatase (G-6-Pase). Results: SSE contained phenols, flavonoids, steroids/triterpenoids, saponins, tannins, and alkaloids. The antioxidant and antidiabetic activities of samples were calculated based on median inhibitory concentration (IC50). The IC50 values of SSE antioxidant, respectively, were DPPH (IC50 = 62.72 μg/mL), ABTS (IC50 = 61.03 μg/mL), H2O2 (IC50 = 438.36 μg/mL), the highest FRAP activity was 125.31 μM Fe(II)/μg extract at a concentration level of SSE 50 μg/mL. The IC50 values of SSE antidiabetic were α-amylase inhibition (IC50 = 37.86 μg/mL), α-glucosidase inhibition (IC50 = 90.41 μg/mL), and G-6-Pase inhibition (IC50 = 98.07 μg/mL), respectively. Conclusions: SSE has antidiabetic potential through antioxidant activities and α-glucosidase, α-amylase, and G-6-Pase inhibition activities.

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