Year : 2021 | Volume
: 10 | Issue : 2 | Page : 198--208
Solid SMEDDS: An approach for dissolution rate enhancement using telmisartan as model drug
Ashish Y Pawar1, Yogesh S Harak1, Santosh R Tambe1, Swati G Talele2, Deepak D Sonawane3, Deelip V Derle4
1 Department of Pharmaceutics, MGV’S Pharmacy College, Nashik, Maharashtra, India
2 Department of Pharmaceutics, Sandip Institute of Pharmaceutical Sciences, Nashik, Maharashtra, India
3 Department of Pharmaceutics, Divine College of Pharmacy, Nashik, Maharashtra, India
4 Department of Pharmaceutics, MVP’s College of Pharmacy, Nashik, Maharashtra, India
Bioavailability improvement of poorly water-soluble drugs is a challenging task for many of the drug candidates. In recent years, an area that is ahead in popularity for different formulation expertise is the use of lipid-based careers to formulate self-emulsifying drug delivery systems (SEDDS) for enhancing the oral bioavailability of lipophilic drugs. The self-microemulsifying drug delivery systems (SMEDDS) are thermodynamically stable and isotropic solutions containing an oil, surfactant, co-surfactant (CoS; or solubilizer), and mixtures of drug which forms oil-in-water microemulsions when incorporated in water and stirred. Different techniques are available to convert liquid–self-microemulsifying drug delivery systems (L-SMEDDS) to solid among which an adsorption technique is economical and very simple. The solid–self-microemulsifying drug delivery systems (S-SMEDDS) of telmisartan (TEL) was developed in the present study which is a poorly water-soluble drug. Different formulations of L-SMEDDS were developed using Capmul PG 8 as oil, Cremophor RH 40 as a surfactant, and Transcutol P as a CoS and were later transformed to S-SMEDDS. The formulations were assessed for dilution study by visual observation, differential scanning calorimetry, analysis of solid S-SMEDDS morphologically, in vitro dissolution test, zeta potential measurement, etc. Significantly higher drug release was observed from S-SMEDDS as compared to plain TEL. Hence, it can be concluded that the adsorption technique is a promising approach for the formulation of S-SMEDDS with improved dissolution rate and concomitantly bioavailability.
Dr. Ashish Y Pawar
Department of Pharmaceutics, MGV’S Pharmacy College, Panchavati, Nashik, Maharashtra 422 003.
|How to cite this article:|
Pawar AY, Harak YS, Tambe SR, Talele SG, Sonawane DD, Derle DV. Solid SMEDDS: An approach for dissolution rate enhancement using telmisartan as model drug.J Rep Pharma Sci 2021;10:198-208
|How to cite this URL:|
Pawar AY, Harak YS, Tambe SR, Talele SG, Sonawane DD, Derle DV. Solid SMEDDS: An approach for dissolution rate enhancement using telmisartan as model drug. J Rep Pharma Sci [serial online] 2021 [cited 2023 Feb 3 ];10:198-208
Available from: https://www.jrpsjournal.com/article.asp?issn=2322-1232;year=2021;volume=10;issue=2;spage=198;epage=208;aulast=Pawar;type=0